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4 edition of Rapid hyaluronan uptake is associated with enhanced motility and transformation found in the catalog.

Rapid hyaluronan uptake is associated with enhanced motility and transformation

Rapid hyaluronan uptake is associated with enhanced motility and transformation

implications for an intracellular mode of action.

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  • 33 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1999.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL19925034M
ISBN 100612458776
OCLC/WorldCa47270228

Among the protein-based hydrogel-forming polymers, various salts of hyaluronic acid (HA), aka hyaluronan or sodium hyaluronate, are used to prepare : Farid Menaa. Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action. FEBS Lett. ; – Crossref Medline Google Scholar; 4 Brown JJ, Papaioannou VE. Ontogeny of hyaluronan secretion during early mouse development. Development. ; – Medline Google ScholarCited by:

Hyaluronan-mediated motility receptor (HMMR), also known as RHAMM (Receptor for Hyaluronan Mediated Motility) is a protein which in humans is encoded by the HMMR gene. RHAMM recently has been also designated CD (cluster of differentiation ).Aliases: HMMR, CD, IHABP, RHAMM, . The first reported functional domains of RHAMM were its hyaluronan binding motifs present in D5, which encode sequences of basic amino acids that are also common to other intracellular hyaladherins, such as cdc37 and p 1 These domains are the sole hyaluronan-binding sites of RHAMM and are key to generating a motility signal from exogenous.

  In , hyaluronan was demonstrated to bind specifically and with high affinity to intact cells (), and in , it was shown to enhance cell motility on two-dimensional culture surfaces where the hydrodynamic properties of hyaluronan were not necessary to open spaces for cells to move into ().These two demonstrations raised the possibility that hyaluronan had the potential to directly modify. Knudson W. Tumor associated hyaluronan. Providing an extracellular matrix that facilitates invasion. Am J Pathol. ; – [PMC free article] Collis L, Hall C, Lange L, Ziebel M, Prestwich R, Turley EA. Rapid hyaluronan uptake is associated with enhanced motility: implication for an intracellular mode of action. FEBS by:


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Rapid hyaluronan uptake is associated with enhanced motility and transformation Download PDF EPUB FB2

Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action. Collis L(1), Hall C, Lange L, Ziebell M, Prestwich R, Turley EA.

Author information: (1)The Hospital for Sick Children, Division of Cardiovascular Research, Toronto, Ont Cited by: Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action Author links open overlay panel L Collis a C Hall b L Lange b M Ziebell c R Prestwich c E.A Turley aCited by: RAPID HYALURONAN UPTAKE IS ASSOCLATED WITH ENHANCED MOTILITY AND TRANSFORMATION: IMPLICATIONS FOR AN INTRACELLULAR MODE OF ACTION Lisa Janine Collis A thesis submitted in conformity with the requirements for the Degree Master of Science, Graduate Department of Anatorny and Ce11 Biology University of TorontoAuthor: Lisa Janine Collis.

Key words: Hyaluronan; RHAMM; CD44; Internalization; Lamella; Nucleus 1. Introduction RHAMM is an hyaladherin that occurs at several subcel-lular loci including the cell surface, cytoplasm and nucleus [1^ 3].

An intracellular as well as surface form of RHAMM reg-ulates cell motility and controls the cell cycle. TR-HA uptake is blocked by: excess polymeric HA, HA-dodecasaccharide, colchicine, BrefeldinA, and by digestion of TR-HA with hyaluronidase. Uptake is dose dependent, saturable and strongly enhanced upon cell attachment, monolayer wounding and : Lisa Janine Collis.

However, in patients who have breast and prostate carcinomas, both hyaluronan that is associated with tumour cells and stromal hyaluronan are linked with cancer progressCited by: Collis L, Hall C, Lange L, Ziebell M, Prestwich R, Turley EA: Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of Cited by: Hyaluronan (HA) is found in the extracellular matrix of many tissues where it is thought to promote cell migration and proliferation.

Recent data suggests that hyaluronan-dependent pericellular matrix formation is a rapid process which occurs as cells detach during mitosis and by: 1. Accepted on Decem ; Introduction. Hyaluronan (also called hyaluronic acid or hyaluronate) is a linear glycosaminoglycan composed of repeating disaccharides of glucuronic acid and N-acetylglucosamine:[β1,4-GlcUA-β1,3-GlcNAc-] usually contains –25, disaccharides, exhibits varying molecular weights ranging from 10 5 to 10 7 Da, and has an extended length of up to Cited by: LMW HA interactions with CD44 are associated with certain pathological conditions, including inflammation, cancer, and induction of angiogenesis (23, 33, –).

Hyaluronan chains can be organized into ECM structures by association with binding by: Hyaluronan at lower concentrations is internalized by receptor mediated uptake, but at higher concentrations in the incubation medium, fluid phase uptake also takes place.

The receptor mediated uptake does not utilize coated pits or : Raija Tammi, Kirsi Rilla, Juha-Pekka Pienimäki, Michael Hogg, Donald K. MacCallum, Vincent C. Hascal. HYALURONIC ACID HYDROGEL FILM: A NEW BIOMATERIAL FOR DRUG DELIVERY AND WOUND HEALING Yi Luo', Kelly R. Kirker", & Glenn D.

Prestwich',t,2 'Department of Medicinal Chemistry, The University of Utah, 30 South East, RoomSalt Lake City, Utah USA 'Department of Bioengineering, The University of Utah, 20 South East, RoomSalt Lake City, Utah ]2 Cited by: 2.

RHAMM was originally described as a hyaluronan binding protein that is present on the cell surface as well as inside the cell and that regulates cell motility and cell cycle. It has been reported to occur as multiple protein forms, some of which are generated by alternative splicing of mRNA.

RHAMM occurs in several sub-cellular : R. Harrison, F.-S. Wang, E.A. Turley. The hyaluronan receptor belongs to the polymorphic family of CD44 glycoproteins, which have been implicated in a variety of cellular functions including adhesion to hyaluronan and collagen, the binding of lymphocytes to high endothelial cells during extravasation, and conferring metastatic potential to carcinoma cells.

Here, we demonstrate that the receptor also participates in the uptake and. Here, we show that HA-promoted random motility of ras-transformed 10T1/2 (C3) fibroblasts requires activation of protein kinase C and is associated with rapid uptake of HA in a CD44 and RHAMM.

1. Introduction. Vascular proliferative disorders such as atherosclerosis, restenosis or allograft rejection are characterized by arterial smooth muscle cells (ASMC) proliferation and migration associated with marked changes into extracellular matrix (ECM).Hyaluronan (HA) is a high molecular weight polysaccharide (–10, kDa) widely distributed in ECM of a variety of tissues including Cited by:   Collis L, Hall, C Lange L, Ziebell M, Prestwich R, Turley EA: Rapid hyaluronan uptake is associated with enhanced motility: implications for.

Hyaluronan is particularly prominent in the matrix of tissues and cells undergoing rapid proliferation, 23 including the matrix of malignancies.

24 Previously, it was shown that hyaluronidase treatment of cultured tumor cells caused eradication of hyaluronan, as well as several CD44 variant isoforms. The current experiments confirmed that CD44s Cited by:   HA is present predominantly in the ECM, particularly in embryonic and malignant tissues.

It occurs early in the ECM of the healing wound (Longaker et al., ) and whenever rapid repair and regeneration is also highly expressed in the glycocalyx, the pericellular coat that ensheathes most cells, and is particularly prominent on the apical surface of endothelial cells (Henry and Cited by:   Collis L, Hall C, Lange L, Ziebell M, Prestwich R, Turley EA.

Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of Cited by:. However, of most interest, coincident with the reduction in hyaluronan, there was a substantial decrease in cell proliferation, a decrease in cell motility and a decrease in cell invasiveness.

These data suggest that hyaluronan synthesized by HAS-2 in MG plays a crucial role in osteosarcoma cell proliferation, motility and by: Elevated Hyaluronan and Hyaluronan-Mediated Motility Receptor Are Associated With Biochemical Failure in Patients With Intermediate-Grade Prostate Tumors Article (PDF Available) in Cancer (Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action 22 December | FEBS Letters, Vol.No.

3 The Active Streptococcal Hyaluronan Synthases (HASs) Contain a Single HAS Monomer and Multiple Cardiolipin MoleculesCited by: